SESMI

http://www.nejm.org/doi/pdf/10.1056/NEJMcibr1006936

Systemic lupus erythematosus (SLE) is a complex
systemic autoimmune disease that predominantly
affects the kidneys in the form of lupus nephritis,
although multiple organs can be involved. Lupus
nephritis is characterized by the deposition in
glomeruli of immune complexes formed by IgG,
IgM, and IgA autoantibodies (which collectively
are called antinuclear antibodies). These autoantibodies
are directed toward ubiquitous nuclear antigens,
particularly double-stranded DNA.1 Deposition
of these complexes can result in renal
failure and even death.